I kind of like this actually.
It could be something like this: The player finds a very large blast door blocking his/her way (Let us assume, since the map is randomly generated, that this is the only path forward for the player.) The player would then have to enter a pass code or use an Omni-card to enter. The player would then see a series of locking mechanisms disengaging, afterwards the doors finally open. The player walks into a very large open room, above are Catwalks and control rooms protected by re-enforced walls, the player would see a large vat a short distance away, and a series of lights will turn on above and below (as in lights built into the floor) to illuminate the entire area (Due to the AI, to show the player what he/she is up against.)
As the player approaches the vat they would hear 682 gurgle and taunt the player, perhaps even making fun of him/her on their encounters with various SCP's (Depending on which ones the players had encountered.) the player would then see 682's skull press against the vat, looking at the player (slowly, not a jump type of thing). After a few more lines the AI would announce that he was able to disengage some of the security measures for 682, 682 would then laugh and claim that he could have gotten out anyway, he then would begin to thrash about, eventually shattering the vat, swinging his none-disintegrated limbs all around, smashing the lights, causing some to stop working or flicker violently. The acid would then spill all over various parts of the room, and combined with his thrashing would create cracks in the ground. At this point 682 would begin to violently regenerate, and the player would have to basically run through a debris filled obstacle coarse to reach a hole in a wall. (Since it's a randomly generated map, the hole could be anywhere.)
I think this could really unnerve the player since the lights would be flickering rapidly, various parts of the walls and floors would be collapsing all around, and the size of 682 combined with his very violent thrashing, regeneration, and screams/roars could really cause panic.
When I imagine the regeneration part I think of the Hunter from Dead Space:
https://www.youtube.com/watch?v=_XjBVdi_BgQ
And referring to the whole hearing him through the radio: Perhaps if the player doesn't visit his room in a certain amount of time they would hear the sounds on the radio, but if they do find his room, they would find it in a completely destroyed state.