Here's a small mockup i did to give an idea of a possible GUI design.
This takes away the whole transparent-10-blocks-gui and makes it a whole new screen instead. This screen lets you see basic information about what has happened to you (nothing more than the average person could know), and implements a humanoid figure that represents 9341.
Different parts of 9341 will highlight in different colours depending on what has happened to him, for example, if he was shot in the leg, his leg will turn red, with a bullet decal being placed in the leg area. At first it will be a pale red and it will worsen as time passes/more hits are received.
Things like memetic effects can be represented too, by using a pale dark purple colour on the head, boosts in green, and diseases in yellow.
This GUI design also incorporates representing status effects, for example our Class D was shot a few minutes ago and had to go through a lockroom without a gas mask to escape the MTF, small squares will appear saying exactly what's wrong right now, bleeding (due to being shot), crippled (limping from the shot), coughing and low stamina (from staying too long in the gas), and quick blinking (due to staying in the gas.)
Also things like being able to read documents on the spot and equipping items is represented, equipping the radio on the left hand and keycard on the right would let you listen to whats going on while still being able to open keycard doors, or doing something like equipping a SCP-500 pill on the left hand would make 9341 be able to take the pill just by clicking the right click.
Healing must be done by dragging the first aid kid to an affected body part, after the process is done the red colour will slowly fade from the limb. (Depending if healing is succesful or not)
I can make a few more of these representing various situations like being hit by 106, being affected by a memetic effect, or having drunk a cup of life.