That could make sense because if one member of the personnel gets infected, he/she could infect other people before getting terminated/cured; so keeping the SCPs that can infect someone in a separated underground area could reduce the possibility for the illness to expand in the facility (and having a separate zone in the facilty only for 049 seems a bit pointless in my opinion. Yeah, it can make easier to control him and avoid possible infections but even that seems a bit exxagerated...).
Since SCP-860 (and another ultra-secrer SCP...) will be added in future versions, I think that "merging" the rooms of these three SCPs by putting them in a small area should not give the idea of "lacking of SCPs" in the higher level of the facility...
SCPs IN THE AREA:
SCP-049 (+ some SCP-049-2, aka the zombies, wandering in the area...)
SCP-035 + SCP-148 (SCP-148 is not a byological hazard, but it should be in this zone because you can find it only in SCP-035's room...)
SCP-008
A POSSIBLE SHAPE OF THE AREA:
Spoiler
-------------------------I know I already suggested that in another discussion but the idea was "too off-topic" so I edited the post and deleted the useless part, moving it there.
I hope that's not considered spamming...
Probably it would be hard to make this big area to not collide with the Maintenance Tunnel...
This is just a suggestion based of my personal idea of 049's containment area (it's nothing official or confirmed...), what do you think about it?